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How we age : the science of longevity / Coleen T. Murphy.

by Murphy, Coleen T.

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Princeton University Press, 2023.

Biochemical genetics.

9780691182636 (hc.)

xv, 440 p. : ill. (black and white) ; 24 cm.

Coleen T. Murphy is Director of the Lewis Sigler Institute of Genomics and professor of Genomics and Molecular Biology at Princeton University. She is also director of Princeton's Glenn Foundation for Research on Aging and the director of the Simons Collaboration on Plasticity in the Aging Brain.

Includes bibliographical references (pages 349-416) and index.

"All of us would like to live longer, or to slow the debilitating effects of age. In 'How We Age,' Coleen Murphy [Director of the Lewis Sigler Institute of Genomics and professor of Genomics and Molecular Biology at Princeton University] shows how recent research on longevity and aging may be bringing us closer to this goal. Murphy explains that the study of model systems, particularly simple invertebrate animals, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging. Understanding the fundamental biological rules that govern aging in model systems provides clues about how we might slow human aging, which could lead in turn to new therapeutics and treatments for age-related disease. Among other vivid examples, Murphy describes research that shows how changing a single gene in the nematode worm C. elegans doubles its lifespan, extending not only the end of life but also the youthful, healthy part of life. Drawing on work in her own lab as well as other recent research, Murphy chronicles the history and current state of the field, explaining longevity's links to reproduction and mating, sensory and cognitive function, inheritances from our ancestors, and the gut microbiome. Written with clarity and wit, 'How We Age' provides a guide to the science: what we know about aging, how we know what we know, and what we can do with this new knowledge."

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