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Rigor mortis : how sloppy science creates worthless cures, crushes hope, and wastes billions / Richard Harris.

by Harris, Richard F.

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Basic Books, an imprint of Perseus Books, a subsidiary of Hachette Book Group, 2017.

Medicine -- Research -- Methodology.

Medical ethics.

9780465097906 (hc.)

vii, 278 pages ; 22 cm.

Includes bibliographical references and index.

Begley's bombshell -- It's hard even on the good days -- A bucket of cold water -- Misled by mice -- Trusting and untrustworthy -- Jumping to conclusions -- Show your work -- A broken culture -- The challenge of precision medicine -- Inventing a discipline.

"American taxpayers spend $30 billion annually funding biomedical research. By some estimates, half of the results from these studies can't be replicated elsewhere - the science is simply wrong. Often, research institutes and academia emphasize publishing results over getting the right answers, incentivizing poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence. How are those with breast cancer helped when the cell on which 900 papers are based turns out not to be a breast cancer cell at all? How effective could a new treatment for ALS be when it failed to cure even the mice it was initially tested on? Science journalist Richard F. Harris reveals these urgent issues with vivid anecdotes, personal stories, and interviews with the nation's top biomedical researchers. We need to fix our dysfunctional biomedical system now"--Provided by publisher.

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